Tracking the effects of concussions

September 4, 2023

We are only beginning to understand the effects of a traumatic brain injury. By improving our understanding of the initial damage from a TBI and the body’s response to a TBI, we can gain insight into long-term brain pathology and improved treatment methods. The work by Dr. Shi is invaluable in this regard while also providing a new avenue to conduct TBI research.

Clayton Houck

Licensing Associate – Life Sciences

PROBLEM
The effect of traumatic brain injury can be observed after decades have passed, but it is difficult to trace back to its origins.

SOLUTION
Researchers at Purdue University have developed “traumatic brain injury (TBI) on a chip.” The device makes it possible to track the effects of concussive force on a functioning cluster of brain cells. The device can be used to test possible therapeutics for TBI, including drugs known to reduce the levels of acrolein, a molecule associated with neurodegenerative disease.

PRIMARY INVESTIGATOR
Riyi Shi, the Mari Hulman George Endowed Professor of Applied Neuroscience in Purdue University’s College of Veterinary Medicine

IN THE MEDIA
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LICENSING CONTACTS
Email: otcip@prf.org

MEDIA CONTACT
Email: Steve Martin // sgmartin@prf.org